The Antonine Plague, sometimes referred to as the Plague of Galen, erupted in 165 CE, at the height of Roman power throughout the Mediterranean world during the reign of the last of the Five Good Emperors, Marcus Aurelius Antoninus (161-180 CE). The first phase of the outbreak would last until 180 CE affecting the entirety of the Roman Empire, while a second outbreak occurred in 251-266 CE, compounding the effects of the earlier outbreak. It has been suggested by some historians that the plague represents a useful starting point for understanding the beginning of the decline of the Roman Empire in the West but also the underpinning to its ultimate fall.
This is a companion discussion topic for the original definition at https://www.worldhistory.org/Antonine_Plague/.
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